England will welcome new debutant and excellently named Billy Twelvetrees to the England midfield and he will line up alongside Brad Barritt in the England midfield for the game against Scotland.
Twelvetrees comes in for the injured Tuilagi who will be sorely missed and the Gloucester centre has some big boots to fill.
However I have no doubt that he will for he is an excellent player and has a good kicking game to bring to the table as well.
Alex Corbisiero has also been ruled out of the Six Nations with a knee problem with Joe Marler replacing him so whilst the injuries are not a calamity there is reasonable doubt in this English team and they will be pleased that they start against arguably the weakest side in this years tournament.
Please don't hate email me you Scots fans!
Tom Youngs will keep the hooker's jersey in place of the more experienced Dylan Hartley, who missed the autumn series through injury and is unlucky to miss out here.
"We are happy to stick with the team that did so well against New Zealand, especially in light of the fact that they have all been in good form for their clubs since then," Lancaster said.
"There were some very tight calls, with some experienced players coming back into contention, and I am sure the bench will have a significant impact on the game."
At the time of writing Scotland have yet to announce their team but there is no reason not to think an England victory is going to be the result.
Jim Hamilton and Richie Gray are two of the Scottish big men who will try and throw a spanner in the works but whilst they have solidity and brawn they lack flair and will struggle to move the ball purposefully.
England XV: A Goode (Saracens); C Ashton (Saracens), B Barritt (Saracens), B Twelvetrees (Gloucester), M Brown (Harlequins); O Farrell (Saracens), B Youngs (Leicester), J Marler (Harlequins), T Youngs (Leicester), D Cole (Leicester), J Launchbury (Wasps), G Parling (Leicester), T Wood (Northampton), C Robshaw (Harlequins, capt), B Morgan (Gloucester)
Replacements: D Hartley (Northampton), D Wilson (Bath), M Vunipola (Saracens), C Lawes (Northampton), J Haskell (Wasps), D Care (Harlequins), T Flood (Leicester), D Strettle (Saracens)
England are 1/11 so you won't be wanting to put your money in there whilst Scotland are 10/1 which is also not value.
The draw is 40/1 but unlike the game between Italy and France which I think will be a lot closer it's a poor bet.