Liverpool make the trip to the Boleyn ground on Tuesday hoping to make further progress in a competition in which to date they have fielded teams filled from the youth ranks to counter the unprecedented injury crisis at the club.
Just as all the players to begin to return from injury so Liverpool are beset with new ones with Lovren and Allen both the latest to be sidelined by injury. Both would have been certain starters on Tuesday.
The good news is that Coutinho, Sturridge and Origi will all be available for the West Ham game and that will strengthen the team and bench for the crucial run of games leading up to the Capital One cup final.
Liverpool have played well in their last few games but have made catastrophic defensive howlers to gift the opposition goals at the most in opportune moments, letting a two goal lead slip to Sunderland with just minutes to go the latest in a series of defensive blunders.
The Reds go into this game on a run of one win in six Premier League games that began with a 2-0 loss to West Ham at Anfield in early January so although performance have been decent results have just not gone their way.
Without several late, late goals Liverpool could be in bottom half of the table obscurity.
So for the fourth time this season these two teams meet with West Ham having two victories and and one drawn game to their credit. Will they be able to inflict more misery on Jurgen Klopp's side?
Certainly if the Liverpool manager persists with his policy of playing youth then Liverpool will struggle against a solid West ham side and with home advantage you have to fancy the Hammers to progress.